MIFit+ is a automatic macromolecular crystal structure solution software suite. Running on both Windows and Linux platforms, MIFit+ includes the MIFit program for crystallographic model-building and the MIExpert program for running external crystallographic calculations.

MIExpert provides robust 'expert' management of crystallographic calculations including image data processing, SAD phasing, molecular replacement and refinement. MIExpert includes a pipeline process for delivering prerefined protein models and maps for co-crystal structure determination plus a tool for ligand-density docking.

MIFit+ features include:

• Reads diffraction data in CCP4 (mtz) and mmCIF formats and density maps in CCP4 and xfit map formats
• Ligand dictionary editor to set refinement restraints with data import in mmCIF, PDB, MOL, and SMILES formats
• Built-in automatic ligand density docking
• A tool for efficiently and accurately overlapping multiple ligands in a target site
• Expert systems for:
  • automated image data processing with d*TREK
  • automatic protein:ligand structure solution
  • molecular replacement allowing searches over multiple models and multiple space groups
  • refinement with automatic error checking and result collection
• Use of industry standard CCP4 and SHELX computation programs (not included) as well as proprietary fitting algorithms
• Runs on Windows and Linux