XtalView is a complete package for solving a macromolecular crystal structure by isomorphous replacement, including building the molecular model. It has been widely used for many years and runs on Sun, DEC, SGI, IBM and PC/Linux computers It has a simple but comprehensive graphic user interface. The main menu drives a suite of crystallographic modules by click of an icon. XtalView maintains log files of all the computations done as a record of your work. Standard file formats are used, which facilitates communication between XtalView and other crystallographic programs.

XtalView is described in the book Practical Protein Crystallography by Duncan McRee, who also designed the program.